Phenylalanine side effects

There are three kinds of phenylalanine. These include L-phenylalanine which is a natural form, D-phenylalanine an artificial version and DLPA which is a combination of the L and D types. The first type can be found in the brain while the other two types will not be synthesized by the body. Thus, they are required to be supplemented externally through our diet. Nutritional supplements that contain this amino acid are promoted in case of deficiency symptoms. However, the safety of phenylalanine supplements must be thoroughly scrutinized before using them for health purpose. The information given below will explain regarding the possible side effects of phenylalanine.

• Side effects of phenylalanine are pronounced in individuals who have a medical history of phenylketonuria or PKU. This is a metabolic disorder which is characterized by the lack of enzyme in order to process phenylalanine. Hence, phenylalanine is stored in the body.

• For kids who are affected with PKU and ADHD, to provide a low dose of external phenylalanine or foods that contain aspartame is associated with medical complications which are life-threatening. On the other hand, adult patients can experience mild to severe effects according to the intake dose.

• In individuals with high blood pressure, phenylalanine can worsen the existing condition by increasing more the blood pressure. Hence, patients with hypertension should not use this amino acid supplement.

• With regard to phenylalanine dose, 500 mg of L-phenylalanine each day is considered safe. The daily dose of DLPA can range from 75 to 1,500 mg. The use of excess dose can increase the risk for the presence of side effects.

• Phenylalanine has a direct effect on the neural tissues. It is strictly not advisable for lactating mothers as well as pregnant women. Also, patients who have underlying medical problems must avoid the use of the amino acid supplement.

• If concentration of DLPA is increased or its intake is prolonged, this can result to heartburn, feeling of nausea and headache. If the concentration is higher, the side effects will be more severe as well. This can even result to cellular death.

• Phenylalanine has also interaction effects with other drugs. Therefore, those who are presently using hypertension drugs and antidepressants particularly the ones that contain monoamine oxidase inhibitors must not use phenylalanine. Moreover, it should not be used along with high protein diet.

• People suffering from hyperthyroidism, cancer and schizophrenia must ask for approval from the doctor before the use of phenylalanine supplement. Failure to do so can lead to uncommon side effects of phenylalanine.

• The consumption of high phenylalanine can increase the risk for mental as well as behavioral problems. When it comes to overdose of this neurotoxin, there are some incidences of irreversible damage of the tissues of the brain and eventually, death of patients.

• Overdose of phenylalanine can result to symptoms of toxicity and can cause nervous breakdown. The lethal dose of phenylalanine will vary according to the type of supplement.

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